Business 100 - 2010

John Crowley/Amicus Therapeutics

John Crowley is the president & CEO of Amicus Therapeutics, a publicly held biopharmaceutical company developing drugs to treat genetic diseases. His involvement stems from the 1998 diagnosis of his children, Megan and Patrick, with Pompe disease: a rare and fatal neuromuscular disorder. Megan and Patrick were given months to live. John helped to co-found a biotech company called Novazyme Pharmaceuticals, focused exclusively on developing a treatment for Pompe. The company went from a $1 million angel financing to $27 million in venture capital financing and was acquired for nearly $200 million by Genzyme Corporation. In 2003, Patrick and Megan began an experimental enzyme therapy developed by Genzyme that has saved their lives. The Crowley family story was featured in the movie Chasing Miracles, starring Harrison Ford and Brendan Fraser, and in a memoir by John entitled Chasing Miracles: The Crowley Family Journey of Strength, Hope and Joy. John graduated from Georgetown, Notre Dame and Harvard. He lives in Princeton, NJ with his wife Aileen, Megan, Patrick, and their oldest son John Jr.